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Introduction Substance use and impaired driving increase risk of motor vehicle crashes and deaths. Individual, socio-economic and -cultural factors are associated with these at-risk behaviors; however, little is known if differences exist between the Anglophone majority and minority Francophone populations in Canada. This article describes prevalence of substance use, impaired driving and driving practices by postsecondary student and compares Francophones and Anglophones with respect to these behaviors. Methods Postsecondary students between 18 and 24 years attending a Francophone university in Western Canada completed a paper-based survey during class-time. Results Prevalence of alcohol consumption, binge drinking and marijuana use in the past month were 88.6%, 64.2% and 22.7% respectively. Francophone participants were more likely to consume more alcohol, participate in drinking games, and consume marijuana during the past month than Anglophones. They were also more likely to report impaired-driving, speeding, distracted driving and being passenger in a motor vehicle driven by an impaired driver. Conclusion Awareness campaigns on campus highlighting the risks of substance use and unsafe driving practices should be strengthened and target Francophone students in linguistic minority communities.